Triethylamine → 5-Chloro-N-[2-(dimethylamino)ethyl]-2-thiophenesulfonamide
반응식
[CH3:1][N:2]([CH3:6])[CH2:3][CH2:4][NH2:5].[Cl:7][C:8]1[S:12][C:11]([S:13](Cl)(=[O:15])=[O:14])=[CH:10][CH:9]=1.C(N(CC)CC)C>C1COCC1>[CH3:1][N:2]([CH3:6])[CH2:3][CH2:4][NH:5][S:13]([C:11]1[S:12][C:8]([Cl:7])=[CH:9][CH:10]=1)(=[O:15])=[O:14]참가 물질
5
실험 절차
To a stirred solution of 2-dimethylamino-ethylamine (1.61 g, 13.8 mmol) in THF (20 mL) was added at 0° C. (ice water bath) commercially available 5-chloro-thiophene-2-sulfonyl chloride (1.0 g, 4.61 mmol) and triethylamine (0.71 mL, 5.07 mmol). The reaction mixture was stirred at room temperature for 16 h and evaporated. The crude product was further purified by flash chromatography (ethyl acetate/MeOH) to yield the title compound (1.23 g, 99%) as a light yellow oil. MS (ISP) 269.0 [(M+H)+].
후처리
- customevaporated
- customThe crude product was further purified by flash chromatography (ethyl acetate/MeOH)
출처 및 근거
- ORD 기록
- ord-7f7fc52525af442f8531155e09defdea
- 출처 데이터셋
- uspto-grants-2011_11
- 특허 번호
- US08063048B2
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