4-Chlorophenylboronic acid → 6-(4-Chloro-phenyl)-8-methyl-imidazo[1,2-a]pyridine

HRID 558595노트

반응식

HRID 558595 반응식
Br[C:2]1[CH:3]=[C:4]([CH3:11])[C:5]2[N:6]([CH:8]=[CH:9][N:10]=2)[CH:7]=1.[Cl:12][C:13]1[CH:18]=[CH:17][C:16](B(O)O)=[CH:15][CH:14]=1>>[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([C:2]2[CH:3]=[C:4]([CH3:11])[C:5]3[N:6]([CH:8]=[CH:9][N:10]=3)[CH:7]=2)=[CH:15][CH:14]=1

참가 물질

3

반응물 2

HCID 742994-Chlorophenylboronic acidHCID 52606476-Bromo-8-methylimidazo(1,2-a)pyridine

생성물 1

HCID 670002626-(4-Chloro-phenyl)-8-methyl-imidazo[1,2-a]pyridine수율 75.2%

실험 절차

Prepared from 6-bromo-8-methyl-imidazo[1,2-a]pyridine (example C.20 step 1) (7.0 g, 33 mmol) and commercially available 4-chlorophenylboronic acid (6.005 g, 36 mmol) as described in example C.20 step 2. Obtained the title compound as a white solid (6.02 g, 75%). MS (ISP) 243.2 [(M+H)+], 245.1 [(M+2+H)+].

출처 및 근거

ORD 기록
ord-f8c5d470412c4887a7534ca950b57672
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08063048B2

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