2-Chloro-N-(1-hydroxy-2-methylpropan-2-yl)thiazole-5-sulfonamide → HCID 86608039, 화합물
반응식
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([C:14]2[CH:19]=[C:18]([C:20]([F:23])([F:22])[F:21])[N:17]3[N:24]=[CH:25][C:26]([C:27]#[CH:28])=[C:16]3[N:15]=2)[CH:7]=[CH:8][C:9]=1[C:10]([F:13])([F:12])[F:11])[CH3:2].[OH:29][CH2:30][C:31]([NH:34][S:35]([C:38]1[S:42][C:41](Cl)=[N:40][CH:39]=1)(=[O:37])=[O:36])([CH3:33])[CH3:32]>>[OH:29][CH2:30][C:31]([NH:34][S:35]([C:38]1[S:42][C:41]([C:28]#[C:27][C:26]2[CH:25]=[N:24][N:17]3[C:18]([C:20]([F:21])([F:22])[F:23])=[CH:19][C:14]([C:6]4[CH:7]=[CH:8][C:9]([C:10]([F:13])([F:11])[F:12])=[C:4]([O:3][CH2:1][CH3:2])[CH:5]=4)=[N:15][C:16]=23)=[N:40][CH:39]=1)(=[O:37])=[O:36])([CH3:33])[CH3:32]참가 물질
3
실험 절차
The title compound was prepared from 5-(3-Ethoxy-4-trifluoromethyl-phenyl)-3-ethynyl-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine (example C.3) (400 mg, 1.0 mmol) and 2-chloro-thiazole-5-sulfonic acid(2-hydroxy-1,1-dimethyl-ethyl)-amide (example B.14) (244 mg, 1.0 mmol) according to general procedure II. Obtained as an orange solid (80 mg, 12%). MS (ISP) 634.1 [(M+H)+]; mp 209-211° C.
출처 및 근거
- ORD 기록
- ord-f279b729c22c4622990da594294d9ff2
- 출처 데이터셋
- uspto-grants-2011_11