Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl 4-ethynylbenzoate → 4-[5-(4-Chloro-phenyl)-7-cyclopropyl-pyrazolo[1,5-a]pyrimidin-3-ylethynyl]-N-methyl-benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl 4-ethynylbenzoate | HCID 15540683 | — |
| 반응물 | 5-(4-Chloro-phenyl)-7-cyclopropyl-3-iodo-pyrazolo[1,5-a]pyrimidine | HCID 67000875 | — |
| 반응물 | NH3 THF MeOH | HCID 86608128 | — |
| 생성물 | 4-[5-(4-Chloro-phenyl)-7-cyclopropyl-pyrazolo[1,5-a]pyrimidin-3-ylethynyl]-N-methyl-benzamide | HCID 11852216 | — |
반응 단계
The title compound was prepared by reacting 5-(4-chloro-phenyl)-7-cyclopropyl-3-iodo-pyrazolo[1,5-a]pyrimidine (example C.5 step 4) (792 mg, 2.0 mmol) and ethyl 4-ethynyl-benzoate (350 mg, 2.0 mmol) according to general procedure II, and subsequently, heating the suspension of the obtained product in 1 M NH3/THF-MeOH (1:1) to 60° C. for 75 h. Obtained as a yellow solid (6 mg, 14%). MS (ISP) 427.3 [(M+H)+]; mp 214-216° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08063048B2 |
| 출처 데이터셋 | uspto-grants-2011_11 |
| ORD ID | ord-5e7c95fa91e64bc2a97d6010072d6052 |
| 출처 메모 | uspto-grants-2011_11 |