홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Ammonium Chloride → HCID 178426906, 화합물

HRID 558969
노트
인쇄 미리보기

반응식

HRID 558969 반응식
[N-:1]=[N+:2]=[N-:3].[Na+].[Cl-].[NH4+].[CH3:7][C:8]1[CH:32]=[C:31]([C:33]([N:35]2[CH2:41][CH2:40][CH2:39][CH2:38][C:37]3[CH:42]=[CH:43][CH:44]=[CH:45][C:36]2=3)=[O:34])[CH:30]=[CH:29][C:9]=1[CH2:10][NH:11][C:12]([N:14]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][C:22]=2[F:24])[N:17]([CH2:25][C:26]#[N:27])[C:16](=[O:28])[CH2:15]1)=[O:13]>CN(C=O)C>[CH3:7][C:8]1[CH:32]=[C:31]([C:33]([N:35]2[CH2:41][CH2:40][CH2:39][CH2:38][C:37]3[CH:42]=[CH:43][CH:44]=[CH:45][C:36]2=3)=[O:34])[CH:30]=[CH:29][C:9]=1[CH2:10][NH:11][C:12]([N:14]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][C:22]=2[F:24])[N:17]([CH2:25][C:26]2[NH:27][N:3]=[N:2][N:1]=2)[C:16](=[O:28])[CH2:15]1)=[O:13]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 25517Ammonium ChlorideHCID 33557Sodium AzideHCID 115844924-Cyanomethyl-8-fluoro-3-oxo-3,4-dihydro-2H-quinoxaline-1-carboxylic acid 2-methyl-4-(2,3,4,5-tetrahydrobenzo[b]azepine-1-carbonyl)benzylamide

생성물 1

HCID 178426906HCID 178426906, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
100 °C

실험 절차

Sodium azide (78 mg, 1.2 mmol) and ammonium chloride (21 mg, 0.40 mmol) were added to a solution of 4-cyanomethyl-8-fluoro-3-oxo-3,4-dihydro-2H-quinoxaline-1-carboxylic acid 2-methyl-4-(2,3,4,5-tetrahydrobenzo[b]azepine-1-carbonyl)benzylamide from Example 13 (210 mg, 0.40 mmol) in DMF (5 ml) and the mixture was stirred at 100° C. for 18 h. The mixture was cooled and evaporated in vacuo. The residue was purified by flash chromatography on silica (eluant CHCl3 100% to CHCl3:methanol;triethylamine 97:2:1 to CHCl3:methanol;triethylamine 94:4:2). The product was partitioned between chloroform and potassium hydrogen sulphate, separated and the organic phase was dried and evaporated in vacuo; yield 33 mg, 15%.

후처리

  1. temperatureThe mixture was cooled
  2. customevaporated in vacuo
  3. customThe residue was purified by flash chromatography on silica (eluant CHCl3 100% to CHCl3:methanol;triethylamine 97:2:1 to CHCl3:methanol;triethylamine 94:4:2)
  4. customThe product was partitioned between chloroform and potassium hydrogen sulphate
  5. customseparated
  6. customthe organic phase was dried
  7. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-8f6b48b1178a430aaba52428b526211f
출처 데이터셋
uspto-grants-2011_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08063038B2

반응 노트

불러오는 중…

이 페이지에서참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트