Imidazole → 1-(2-fluoro-4-nitrophenyl)-1H-imidazole

HRID 559005노트

반응식

HRID 559005 반응식
[F:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[CH:5]=[CH:6][C:7]=1F.[NH:12]1[CH:16]=[CH:15][N:14]=[CH:13]1.C([O-])([O-])=O.[K+].[K+].O>CN(C=O)C>[F:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[CH:5]=[CH:6][C:7]=1[N:12]1[CH:16]=[CH:15][N:14]=[CH:13]1

참가 물질

6

반응물 4

HCID 795ImidazoleHCID 962WaterHCID 11430Potassium CarbonateHCID 1230531,2-Difluoro-4-nitrobenzene

생성물 1

HCID 53061531-(2-fluoro-4-nitrophenyl)-1H-imidazole수율 96.8%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of 3,4-difluoronitrobenzene (1.00 mL, 9.03 mmol), imidazole (0.615 g, 9.04 mmol) and K2CO3 (2.50 g, 18.1 mmol) in DMF (10 mL) was stirred at room temperature overnight. Water (20 mL) was added to induce precipitation. The precipitate was collected, dried on vacuum to give 1-(2-fluoro-4-nitrophenyl)-1H-imidazole as a solid (1.81 g). MS 208.2 (M+H)

후처리

  1. customprecipitation
  2. customThe precipitate was collected
  3. customdried on vacuum

출처 및 근거

ORD 기록
ord-4b20f4cebb9d42299be69da5564c8cf7
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08063058B2

반응 노트

불러오는 중…