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Sodium Bicarbonate → (5-Bromo-6-methoxypyridin-2-yl)methanol

HRID 559142
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HRID 559142 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:10]C(OC)=O)=[N:6][C:7]=1[O:8][CH3:9].C([O-])(O)=[O:16].[Na+]>CO>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:10][OH:16])=[N:6][C:7]=1[O:8][CH3:9]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

4

반응물 2

HCID 516892Sodium BicarbonateHCID 67001081Methyl 2-(5-bromo-6-methoxypyridin-2-yl)acetate

생성물 1

HCID 58536689(5-Bromo-6-methoxypyridin-2-yl)methanol

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

step d—A solution of 52c (0.060 g), 5% aq. NaHCO3 (2 mL) and MeOH (2 mL) was heated at reflux for 2 h. The reaction mixture was partitioned between H2O and EtOAc and the combined EtOAc extracts were dried, filtered and evaporated in vacuo. The crude product was purified by SiO2 chromatography eluting with 25% EtOAc/hexane to afford 50a.

후처리

  1. temperatureat reflux for 2 h
  2. customThe reaction mixture was partitioned between H2O and EtOAc
  3. dry with materialthe combined EtOAc extracts were dried
  4. filtrationfiltered
  5. customevaporated in vacuo
  6. customThe crude product was purified by SiO2 chromatography
  7. washeluting with 25% EtOAc/hexane

출처 및 근거

ORD 기록
ord-904fb98201924644aa45b8339ea0dcc1
출처 데이터셋
uspto-grants-2011_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08063072B2

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