Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Aminothiazole → 2-(2,3,4-Trimethoxybenzyloxy)-1-nitrobenzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Aminothiazole | HCID 2155 | — |
| 반응물 | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| 반응물 | (2,3,4-Trimethoxyphenyl)methanol | HCID 123571 | — |
| 반응물 | 2-(2,3,4-Trimethoxybenzyloxy)aniline | HCID 66998842 | — |
| 생성물 | N-[2-(2,3,4-trimethoxybenzyloxy)phenyl]-N'-(thiazol-2-yl)urea | HCID 59732707 | 65% |
| 생성물 | 2-(2,3,4-Trimethoxybenzyloxy)-1-nitrobenzene | HCID 66998910 | 72% |
반응 단계
2-(2,3,4-Trimethoxybenzyloxy)-1-nitrobenzene (0.46 g, 72%) was prepared from 2,3,4-trimethoxybenzyl alcohol (0.35 ml, 2.0 mmol) and 1-fluoro-2-nitrobenzene (0.21 ml, 2.0 mmol) following the general procedure G. This was reduced to 2-(2,3,4-trimethoxybenzyloxy)aniline (0.26 g, 65%) following the general procedure B. N-[2-(2,3,4-trimethoxybenzyloxy)phenyl]-N′-(thiazol-2-yl)urea (240 mg, 65%) was prepared from 2-(2,3,4-trimethoxy-benzyloxy)aniline (0.26 g, 0.9 mmol) and 2-aminothiazole (140 mg, 1.4 mmol) following the general procedure D.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08063081B2 |
| 출처 데이터셋 | uspto-grants-2011_11 |
| ORD ID | ord-24bd29b9df844323952d1bf03817cd9e |
| 출처 메모 | uspto-grants-2011_11 |