Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Aminothiazole → N-[2-(2,3-Dimethoxyphenoxy)-3-methylphenyl]-N'-(thiazol-2-yl)urea
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Aminothiazole | HCID 2155 | — |
| 반응물 | 2-Chloro-3-nitrotoluene | HCID 77591 | — |
| 반응물 | 2,3-Dimethoxyphenol | HCID 78828 | — |
| 반응물 | 2-(2,3-Dimethoxyphenoxy)-3-methylaniline | HCID 66999024 | — |
| 생성물 | N-[2-(2,3-Dimethoxyphenoxy)-3-methylphenyl]-N'-(thiazol-2-yl)urea | HCID 59732737 | 61% |
| 생성물 | 2-(2,3-Dimethoxyphenoxy)-3-nitrotoluene | HCID 66998928 | 56% |
반응 단계
2-(2,3-Dimethoxyphenoxy)-3-nitrotoluene (0.80 g, 56%) was prepared from 2,3-dimethoxyphenol (0.85 g, 5.5 mmol) and 2-chloro-3-nitrotoluene (0.85 g, 5.0 mmol) following the general procedure A. This was reduced to 2-(2,3-dimethoxyphenoxy)-3-methylaniline (0.54 g, 76%) following general procedure C. N-[2-(2,3-Dimethoxyphenoxy)-3-methylphenyl]-N′-(thiazol-2-yl)urea (116 mg, 61%) was prepared from 2-(2,3-dimethoxyphenoxy)-3-methylaniline (130 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08063081B2 |
| 출처 데이터셋 | uspto-grants-2011_11 |
| ORD ID | ord-275b2c0af6ee4fd783611fe090757f13 |
| 출처 메모 | uspto-grants-2011_11 |