2-(2-bromo-cyclopent-2-enyl)-N,N-dimethyl-acetamide → 2-(2-Bromo-cyclopent-2-enyl)-ethanol

HRID 560049

반응식

HRID 560049 반응식
[Br:1][C:2]1[CH:3]([CH2:7][C:8](N(C)C)=[O:9])[CH2:4][CH2:5][CH:6]=1.C([BH-](CC)CC)C.[Li+]>C1COCC1>[Br:1][C:2]1[CH:3]([CH2:7][CH2:8][OH:9])[CH2:4][CH2:5][CH:6]=1

참가 물질

4

반응물 2

HCID 219860692-(2-bromo-cyclopent-2-enyl)-N,N-dimethyl-acetamideHCID 23664628Lithiumtriethylborohydride

생성물 1

HCID 219860942-(2-Bromo-cyclopent-2-enyl)-ethanol수율 58%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

2-(2-Bromo-cyclopent-2-enyl)-N,N-dimethyl-acetamide (Intermediate FOUR1) (1.93 g, 8.3 mmol) in THF (50 mL) was reacted with lithium triethylborohydride (19 mL, 1 M in THF) at 0° C. for 1 h. The mixture was treated with an aqueous work-up and the resultant alcohol was purified by column chromatography to give 0.92 g of 2-(2-bromo-cyclopent-2-enyl)-ethanol Intermediate FIVE1.

후처리

  1. additionThe mixture was treated with an aqueous work-up
  2. customthe resultant alcohol was purified by column chromatography

출처 및 근거

ORD 기록
ord-32e1c1c926c54f50a03463db09ce9584
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08063087B2

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