Sodium Carbonate → 3'-(1-Benzenesulfonyl-3-isopropyl-2-oxo-imidazolidin-4-yl)-biphenyl-3-sulfonic acid amide

HRID 560105

반응식

HRID 560105 반응식
[C:1]1([S:7]([N:10]2[CH2:14][CH:13]([C:15]3[CH:20]=[CH:19][CH:18]=[C:17](Br)[CH:16]=3)[N:12]([CH:22]([CH3:24])[CH3:23])[C:11]2=[O:25])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.B([C:29]1[CH:30]=[C:31]([S:35]([NH2:38])(=[O:37])=[O:36])[CH:32]=[CH:33][CH:34]=1)(O)O.C(=O)([O-])[O-].[Na+].[Na+]>O1CCOCC1.O.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2].ClCCl>[C:1]1([S:7]([N:10]2[CH2:14][CH:13]([C:15]3[CH:16]=[C:17]([C:29]4[CH:34]=[CH:33][CH:32]=[C:31]([S:35]([NH2:38])(=[O:37])=[O:36])[CH:30]=4)[CH:18]=[CH:19][CH:20]=3)[N:12]([CH:22]([CH3:24])[CH3:23])[C:11]2=[O:25])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

6

반응물 3

HCID 10340Sodium CarbonateHCID 441193233-(Aminosulphonyl)benzeneboronic acidHCID 670010961-Benzenesulfonyl-4-(3-bromo-phenyl)-3-isopropyl-imidazolidin-2-one

생성물 1

HCID 670010723'-(1-Benzenesulfonyl-3-isopropyl-2-oxo-imidazolidin-4-yl)-biphenyl-3-sulfonic acid amide

시약·촉매·용매 2

HCID 178418807HCID 178418807, 화합물촉매HCID 218864351,4-Dioxane--water (1/1)용매

실험 절차

In analogy to example 1, step 3,1-benzenesulfonyl-4-(3-bromo-phenyl)-3-isopropyl-imidazolidin-2-one (example 12, step 1) was reacted with 3-boronobenzenesulfonamide in the presence of dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium dichloromethane adduct and sodium carbonate in dioxane/water to give 3′-(1-benzenesulfonyl-3-isopropyl-2-oxo-imidazolidin-4-yl)-biphenyl-3-sulfonic acid amide as a colorless solid. MS: 499.9 ([M+H]+)

출처 및 근거

ORD 기록
ord-242f97bfa5994943abcfaa83ab56936b
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08063088B2

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