Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Carbonate → 1-Benzenesulfonyl-4-(5'-ethoxy-2'-fluoro-biphenyl-3-yl)-3-isopropyl-imidazolidin-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 5-Ethoxy-2-fluorophenylboronic Acid (contains varying amounts of Anhydride) | HCID 16217468 | — |
| 반응물 | 1-Benzenesulfonyl-4-(3-bromo-phenyl)-3-isopropyl-imidazolidin-2-one | HCID 67001096 | — |
| 촉매 | HCID 178418807 | HCID 178418807 | — |
| 용매 | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| 생성물 | 1-Benzenesulfonyl-4-(5'-ethoxy-2'-fluoro-biphenyl-3-yl)-3-isopropyl-imidazolidin-2-one | HCID 44548393 | — |
반응 단계
In analogy to example 1, step 3,1-benzenesulfonyl-4-(3-bromo-phenyl)-3-isopropyl-imidazolidin-2-one (example 12, step 1) was reacted with 5-ethoxy-2-fluorophenylboronic acid in the presence of dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium dichloromethane adduct and sodium carbonate in dioxane/water to give 1-benzenesulfonyl-4-(5′-ethoxy-2′-fluoro-biphenyl-3-yl)-3-isopropyl-imidazolidin-2-one as a light yellow oil. MS: 483.2 ([M+H]+)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08063088B2 |
| 출처 데이터셋 | uspto-grants-2011_11 |
| ORD ID | ord-dad9898def3346c8a0439643f885f996 |
| 출처 메모 | uspto-grants-2011_11 |