Cyclopropanecarbothioamide → 5-(4-Cyano-phenyl)-2-cyclopropyl-thiazole-4-carboxylic Acid Methyl Ester

반응식

[CH3:1][O:2][C:3](=[O:16])[C:4](=O)[CH:5](Cl)[C:6]1[CH:11]=[CH:10][C:9]([C:12]#[N:13])=[CH:8][CH:7]=1.[CH:17]1([C:20](=[S:22])[NH2:21])[CH2:19][CH2:18]1>>[CH3:1][O:2][C:3]([C:4]1[N:21]=[C:20]([CH:17]2[CH2:19][CH2:18]2)[S:22][C:5]=1[C:6]1[CH:11]=[CH:10][C:9]([C:12]#[N:13])=[CH:8][CH:7]=1)=[O:16]

참가 물질

반응물 2

HCID 22140884Cyclopropanecarbothioamide

HCID 866442013-Chloro-3-(4-cyano-phenyl)-2-oxo-propionic acid methyl ester

생성물 1

HCID 669191845-(4-Cyano-phenyl)-2-cyclopropyl-thiazole-4-carboxylic Acid Methyl Ester

실험 절차

prepared by reaction of 3-chloro-3-(4-cyano-phenyl)-2-oxo-propionic acid methyl ester with cyclopropanecarbothioic acid amide.

출처 및 근거

ORD 기록: ord-a7cfb93b9aee45259384dc33e40d7374
출처 데이터셋: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08063099B2

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