Allyl bromide → 3-allyloxy-4-fluoro-benzoic Acid Ethyl Ester

HRID 560316노트

반응식

HRID 560316 반응식
C([O-])([O-])=O.[K+].[K+].Br[CH2:8][CH:9]=[CH2:10].[CH2:11]([O:13][C:14](=[O:23])[C:15]1[CH:20]=[CH:19][C:18]([F:21])=[C:17]([OH:22])[CH:16]=1)[CH3:12]>CC(C)=O>[CH2:11]([O:13][C:14](=[O:23])[C:15]1[CH:20]=[CH:19][C:18]([F:21])=[C:17]([O:22][CH2:10][CH:9]=[CH2:8])[CH:16]=1)[CH3:12]

참가 물질

5

반응물 3

HCID 7841Allyl bromideHCID 11430Potassium CarbonateHCID 18007712Ethyl 4-fluoro-3-hydroxybenzoate

생성물 1

HCID 669987353-allyloxy-4-fluoro-benzoic Acid Ethyl Ester

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

K2CO3 (96.9 mmol) and 3-bromo-1-propen (64.6 mmol) are added to a solution of 4-fluoro-3-hydroxy-benzoic acid ethyl ester (32.3 mmol) in acetone (50 mL). The mixture is heated to reflux for 16 h, filtered and cooled to RT. The solvents are removed in vacuo to give the desired product which is used without further purification. LC-MS: tR=1.01 min; [M+CH3CN+H]+=266.0.

후처리

  1. temperatureThe mixture is heated
  2. temperatureto reflux for 16 h
  3. filtrationfiltered
  4. customThe solvents are removed in vacuo

출처 및 근거

ORD 기록
ord-b0f29086079d4af2aca10cfe0353505d
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08063099B2

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