2-Methyl-5-m-tolyl-thiazole-4-carboxylic acid → 2,2,2-Trifluoro-N-[(1S,2S,5R)-3-(2-methyl-5-m-tolyl-thiazole-4-carbonyl)-3-aza-bicyclo[3.1.0]hex-2-ylmethyl]-acetamide
반응식
[C@H:1]12[CH2:6][C@H:5]1[CH2:4][NH:3][C@@H:2]2[CH2:7][NH:8][C:9](=[O:14])[C:10]([F:13])([F:12])[F:11].[CH3:15][C:16]1[S:17][C:18]([C:24]2[CH:25]=[C:26]([CH3:30])[CH:27]=[CH:28][CH:29]=2)=[C:19]([C:21](O)=[O:22])[N:20]=1>>[F:13][C:10]([F:12])([F:11])[C:9]([NH:8][CH2:7][C@H:2]1[N:3]([C:21]([C:19]2[N:20]=[C:16]([CH3:15])[S:17][C:18]=2[C:24]2[CH:25]=[C:26]([CH3:30])[CH:27]=[CH:28][CH:29]=2)=[O:22])[CH2:4][C@H:5]2[C@@H:1]1[CH2:6]2)=[O:14]참가 물질
3
실험 절차
prepared by reaction of N-[(1S,2S,5R)-1-(3-Aza-bicyclo[3.1.0]hex-2-yl)methyl]-2,2,2-trifluoro-acetamide with 2-Methyl-5-m-tolyl-thiazole-4-carboxylic acid.
출처 및 근거
- ORD 기록
- ord-e3c4ea5cf4a14184989c6db13ffb8655
- 출처 데이터셋
- uspto-grants-2011_11