Potassium Carbonate → (5-(Difluoromethyl)furan-2-yl)methanol

HRID 560564노트

반응식

HRID 560564 반응식
C(=O)([O-])[O-].[K+].[K+].C([O:10][CH2:11][C:12]1[O:13][C:14]([CH:17]([F:19])[F:18])=[CH:15][CH:16]=1)(=O)C>CO>[F:18][CH:17]([F:19])[C:14]1[O:13][C:12]([CH2:11][OH:10])=[CH:16][CH:15]=1

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 53728052(5-(Difluoromethyl)furan-2-yl)methyl acetate

생성물 1

HCID 20079677(5-(Difluoromethyl)furan-2-yl)methanol수율 96%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a suspension of potassium carbonate in anhydrous methanol (10%, 50 mL) was added (5-(difluoromethyl)furan-2-yl)methyl acetate (4.21 g, 22.16 mmol). The reaction mixture was stirred at ambient temperature for 20 minutes, filtered and concentrated in vacuo. The residue was purified by column chromatography eluted with ethyl acetate/hexane (3/7) to afford (5-(difluoromethyl)furan-2-yl)methanol as a yellow oil in 96% yield (3.15 g): 1H NMR (300 MHz, CDCl3) δ 6.55 (t, JH-F=54.2 Hz, 1H), 6.58-6.55 (m, 1H), 6.34-6.26 (m, 1H), 4.59 (d. J=5.9 Hz, 2H).

후처리

  1. filtrationfiltered
  2. concentrationconcentrated in vacuo
  3. customThe residue was purified by column chromatography
  4. washeluted with ethyl acetate/hexane (3/7)

출처 및 근거

ORD 기록
ord-bc41e2476d0c4d1d91622ffa9a7097f9
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08063084B2

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