Diethylamine → N-ethyl-N-(2-fluoro-4-iodobenzyl)ethanamine

HRID 56078노트

반응식

HRID 56078 반응식
Br[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([I:9])=[CH:5][C:4]=1[F:10].[CH2:11]([NH:13][CH2:14][CH3:15])[CH3:12]>CCO>[CH2:11]([N:13]([CH2:2][C:3]1[CH:8]=[CH:7][C:6]([I:9])=[CH:5][C:4]=1[F:10])[CH2:14][CH3:15])[CH3:12]

참가 물질

4

반응물 2

HCID 8021DiethylamineHCID 222404061-(Bromomethyl)-2-fluoro-4-iodobenzene

생성물 1

HCID 90022808N-ethyl-N-(2-fluoro-4-iodobenzyl)ethanamine수율 94%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 1-(bromomethyl)-2-fluoro-4-iodobenzene (1.89 g, 6.0 mmol) and a solution of diethylamine (2.19 g, 30 mmol) in EtOH (60 mL) was stirred at rt overnight under N2, then concentrated in vacuo. The residue was dissolved in EtOAc (100 mL), and washed with water (100 mL×3) followed by brine (100 mL). The organic phase was concentrated in vacuo to give the title compound as colorless oil (1.72 g, 94%).

후처리

  1. concentrationconcentrated in vacuo
  2. dissolutionThe residue was dissolved in EtOAc (100 mL)
  3. washwashed with water (100 mL×3)
  4. concentrationThe organic phase was concentrated in vacuo

출처 및 근거

ORD 기록
ord-09eac039fcb240d299595f50e5735ec9
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434695B2

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