4-(2-Fluoro-4-nitrophenyl)-1lambda~6~,4-thiazinane-1,1-dione → 4-(4-Amino-2-fluorophenyl)thiomorpholine 1,1-dioxide

HRID 56098노트

반응식

HRID 56098 반응식
[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]=1[N:11]1[CH2:16][CH2:15][S:14](=[O:18])(=[O:17])[CH2:13][CH2:12]1>C1COCC1.[Pd]>[NH2:8][C:6]1[CH:5]=[CH:4][C:3]([N:11]2[CH2:16][CH2:15][S:14](=[O:17])(=[O:18])[CH2:13][CH2:12]2)=[C:2]([F:1])[CH:7]=1

참가 물질

4

반응물 1

HCID 159843694-(2-Fluoro-4-nitrophenyl)-1lambda~6~,4-thiazinane-1,1-dione

생성물 1

HCID 435813994-(4-Amino-2-fluorophenyl)thiomorpholine 1,1-dioxide

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 4-(2-fluoro-4-nitrophenyl)1,1-dioxidothiomorpholine (4.00 g, 14.58 mmol) in THF (50 mL) was added Pd/C (1.30 g). The reaction mixture was stirred at rt under H2 for 12 h. The mixture was filtered, and the filtrate was concentrated in vacuo to give the title compound as an offwhite solid (2.40 g, 67%).

후처리

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-4b4a2f8296c64eaa909b715e8b62270f
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434695B2

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