Piperidine → 1-(2-Fluoro-4-nitrophenyl)piperidine
반응식
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.CCN(CC)CC.F[C:15]1[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][C:16]=1[F:24]>CCOC(C)=O>[F:24][C:16]1[CH:17]=[C:18]([N+:21]([O-:23])=[O:22])[CH:19]=[CH:20][C:15]=1[N:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1참가 물질
5
실험 절차
To a solution of piperidine (5.88 g, 69 mmol) and Et3N (6.98 g, 69 mmol) in EtOAc (60 mL) was added 1,2-difluoro-4-nitrobenzene (10.00 g, 63 mmol) dropwise. The mixture was stirred at rt overnight. The resulting mixture was washed with brine, dried over anhydrous Na2SO4 and concentrated in vacuo to give the title compound as a yellow solid (14.00 g, 99%).
후처리
- washThe resulting mixture was washed with brine
- dry with materialdried over anhydrous Na2SO4
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-e03d6bb1801d42d4b779a7b74f77f155
- 출처 데이터셋
- uspto-grants-2016_09
- 특허 번호
- US09434695B2
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