Potassium Hydroxide → 9-fluoro-7-nitro-2,3,3a,4-tetrahydro-1H-benzo[b]pyrrolo[1,2-d][1,4]oxazine

참여 물질

역할	이름	HCID	투입량
반응물	Potassium Hydroxide	HCID 14797	—
반응물	L-Prolinol	HCID 640091	—
반응물	1,2,3-Trifluoro-5-nitrobenzene	HCID 2782793	—
용매	Dimethyl Sulfoxide	HCID 679	—
용매	Water	HCID 962	—
생성물	9-fluoro-7-nitro-2,3,3a,4-tetrahydro-1H-benzo[b]pyrrolo[1,2-d][1,4]oxazine	HCID 85365515	93%

반응 조건

온도	65 °C

반응 단계

To a suspension of prolinol (2.74 g, 27.11 mmol) and KOH (3.17 g, 56.47 mmol) in DMSO (30 mL) was added 1,2,3-trifluoro-5-nitrobenzene (4.00 g, 22.59 mmol) at rt. The reaction mixture was heated at 65° C. for 4 h. The mixture was diluted with water (150 mL) and extracted with CH2Cl2 (100 mL×2). The combined organic phases were dried over anhydrous Na2SO4 and concentrated in vacuo to give the title compound as a yellow solid (5.00 g, 93%).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US09434695B2
출처 데이터셋	uspto-grants-2016_09
ORD ID	ord-c8c62219b2a643498f25b0140522e236
출처 메모	uspto-grants-2016_09