참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | p-Toluenesulfonic acid | HCID 6101 | — |
| 반응물 | 2-Bromo-1,1-dimethoxyethane | HCID 81672 | — |
| 반응물 | Benzenecarbothioamide, 4-(diethylamino)- | HCID 28410527 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | N,N-diethyl-4-(thiazol-2-yl)aniline | HCID 20471151 | 55% |
반응 단계
To a solution of 4-(diethylamino)benzothioamide (2.29 g, 11 mmol) in EtOH (60 mL) were added 2-bromo-1,1-dimethoxyethane (1.86 g, 11 mmol) and p-toluenesulfonic acid (1.89 g, 11 mmol). The reaction mixture was heated at 95° C. overnight, then cooled to rt and concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc/Et3N (V/V/V)=2:1:0.05) to give the title compound as a white solid (1.40 g, 55%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09434695B2 |
|---|
| 출처 데이터셋 | uspto-grants-2016_09 |
|---|
| ORD ID | ord-ac4c8fb978c34e78bf800f3165254691 |
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| 출처 메모 | uspto-grants-2016_09 |
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