Sodium Iodide → 4-(Morpholin-4-yl)benzamide

HRID 56114

반응식

HRID 56114 반응식
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][CH:3]=1.[Na+].[I-].C([O-])([O-])=O.[K+].[K+].[CH2:19]([O:22][CH2:23][CH2:24]Cl)[CH2:20]Cl>CN(C=O)C.O>[O:22]1[CH2:23][CH2:24][N:1]([C:2]2[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][CH:3]=2)[CH2:20][CH2:19]1

참가 물질

7

반응물 4

HCID 5238Sodium IodideHCID 8115Bis(2-chloroethyl) etherHCID 11430Potassium CarbonateHCID 760794-Aminobenzamide

생성물 1

HCID 221422424-(Morpholin-4-yl)benzamide수율 64%

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

반응 조건

온도
140 °C

실험 절차

To a solution of 4-aminobenzamide (6.81 g, 50 mmol) in DMF (70 mL) were added NaI (22.48 g, 150 mmol) and K2CO3 (13.82 g, 100 mmol). The mixture was heated to 140° C. and 2,2′-dichlorodiethyl ether (14.30 g, 100 mmol) was added. The reaction mixture was heated at 150° C. for 5 h, and cooled to rt. The mixture was diluted with water (100 mL), stirred for 10 min, and filtered. The filter cake was washed with water and dried to give the title compound as a yellow solid (6.60 g, 64%).

후처리

  1. temperatureThe reaction mixture was heated at 150° C. for 5 h
  2. temperaturecooled to rt
  3. filtrationfiltered
  4. washThe filter cake was washed with water
  5. customdried

출처 및 근거

ORD 기록
ord-c5a4edc26e8649629981307c9899858c
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434695B2

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