p-Toluenesulfonic acid → 4-(4-(Thiazol-2-yl)phenyl)morpholine

HRID 56116

반응식

HRID 56116 반응식
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[CH:15]=[CH:14][C:10]([C:11](=[S:13])[NH2:12])=[CH:9][CH:8]=2)[CH2:3][CH2:2]1.Br[CH2:17][CH:18](OC)OC.C1(C)C=CC(S(O)(=O)=O)=CC=1>CCO>[S:13]1[CH:18]=[CH:17][N:12]=[C:11]1[C:10]1[CH:9]=[CH:8][C:7]([N:4]2[CH2:3][CH2:2][O:1][CH2:6][CH2:5]2)=[CH:15][CH:14]=1

참가 물질

5

반응물 3

HCID 6101p-Toluenesulfonic acidHCID 816722-Bromo-1,1-dimethoxyethaneHCID 27953604-Morpholinobenzenecarbothioamide

생성물 1

HCID 900228674-(4-(Thiazol-2-yl)phenyl)morpholine수율 81.2%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
95 °C

실험 절차

To a solution of 4-morpholinobenzothioamide (2.22 g, 10 mmol) in EtOH (50 mL) were added 2-bromo-1,1-dimethoxyethane (1.69 g, 10 mmol) and p-toluenesulfonic acid (1.90 g, 10 mmol). The reaction mixture was heated at 95° C. overnight, then cooled to rt and filtered. The filter cake was dried to give the title compound as a yellow solid (2.00 g, 81%).

후처리

  1. temperaturecooled to rt
  2. filtrationfiltered
  3. customThe filter cake was dried

출처 및 근거

ORD 기록
ord-f1d7e3e5dde646d382393bff6ab00702
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434695B2

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