Nitric Acid → 4-(4-(5-Nitrothiazol-2-yl)phenyl)morpholine
반응식
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]1[CH:11]=[CH:10][C:9]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)=[CH:8][CH:7]=1.S(=O)(=O)(O)O.[N+:23]([O-])([OH:25])=[O:24]>>[N+:23]([C:5]1[S:1][C:2]([C:6]2[CH:7]=[CH:8][C:9]([N:12]3[CH2:17][CH2:16][O:15][CH2:14][CH2:13]3)=[CH:10][CH:11]=2)=[N:3][CH:4]=1)([O-:25])=[O:24]참가 물질
4
반응 조건
- 온도
- 0 °C
실험 절차
To a mixture of 4-(4-(thiazol-2-yl)phenyl)morpholine (2.00 g, 8.13 mmol) and concentrated sulfuric acid (25 mL) was added concentrated nitric acid (0.60 mL) at −10° C. The reaction mixture was stirred at 0° C. for 4.5 h, then poured into ice water, and extracted with CH2Cl2 (60 mL×3). The organic phase was dried over Na2SO4 and concentrated in vacuo to give the title compound as a yellow solid (0.70 g, 30%).