Trifluoroacetic acid → 4-[2-(Trifluoromethyl)phenoxy]piperidine

HRID 561188

반응식

HRID 561188 반응식
FC(F)(F)C(O)=O.[F:8][C:9]([F:31])([F:30])[C:10]1[CH:29]=[CH:28][CH:27]=[CH:26][C:11]=1[O:12][CH:13]1[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]1>C(Cl)Cl>[F:31][C:9]([F:8])([F:30])[C:10]1[CH:29]=[CH:28][CH:27]=[CH:26][C:11]=1[O:12][CH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 46941590Tert-butyl 4-(2-(trifluoromethyl)phenoxy)piperidine-1-carboxylate

생성물 1

HCID 50187904-[2-(Trifluoromethyl)phenoxy]piperidine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Trifluoroacetic acid (26.3 mL, 342 mmol) was added to a solution of tert-butyl 4-[2-(trifluoromethyl)phenoxy]piperidine-1-carboxylate (29.5 g, 85 mmol) in CH2Cl2 (171 mL). The mixture was stirred at room temperature for 16 h. The solvent was removed by evaporation. The residue was diluted with EtOAc (200 mL), washed with 2 N NaOH (3×100 mL), brine, dried over Na2SO4, and evaporated to give the title compound as an oil.

후처리

  1. customThe solvent was removed by evaporation
  2. additionThe residue was diluted with EtOAc (200 mL)
  3. washwashed with 2 N NaOH (3×100 mL), brine
  4. dry with materialdried over Na2SO4
  5. customevaporated

출처 및 근거

ORD 기록
ord-651f15b3e36345b1b0a76ac5aa3df6c0
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08063224B2

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