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Potassium Carbonate → 5-{4-[2-(Trifluoromethyl)phenoxy]piperidin-1-yl}-1,3,4-thiadiazol-2-amine

HRID 561191
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HRID 561191 반응식
Cl.[F:2][C:3]([F:18])([F:17])[C:4]1[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=1[O:6][CH:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.Br[C:20]1[S:24][C:23]([NH2:25])=[N:22][N:21]=1.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[F:18][C:3]([F:2])([F:17])[C:4]1[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=1[O:6][CH:7]1[CH2:12][CH2:11][N:10]([C:20]2[S:24][C:23]([NH2:25])=[N:22][N:21]=2)[CH2:9][CH2:8]1
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참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 36508832-Amino-5-bromo-1,3,4-thiadiazoleHCID 171780044-(2-(Trifluoromethyl)phenoxy)piperidine hydrochloride

생성물 1

HCID 533883675-{4-[2-(Trifluoromethyl)phenoxy]piperidin-1-yl}-1,3,4-thiadiazol-2-amine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
80 °C

실험 절차

To a solution of 4-[2-(trifluoromethyl)phenoxy]piperidine hydrochloride (5.5 g, 2.2 mmol) in DMF (50 mL) was added 5-bromo-1,3,4-thiadiazol-2-amine (3.3 g, 2.2 mmol) and K2CO3 (9.1 g, 6.6 mmol). The reaction was heated at 80° C. with stirring overnight. After cooling, the salt was removed by filtration and the filtrate was evaporated in vacuo. The residue was triturated with EtOAc to afford the title compound.

후처리

  1. temperatureAfter cooling
  2. customthe salt was removed by filtration
  3. customthe filtrate was evaporated in vacuo
  4. customThe residue was triturated with EtOAc

출처 및 근거

ORD 기록
ord-2cb4ec98707546dbaad3ef52a0d6935d
출처 데이터셋
uspto-grants-2011_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08063224B2

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