3-Fluoro-1-nitro-4-(1H-pyrrol-1-yl)benzene → 3-fluoro-4-(1H-pyrrol-1-yl)aniline
반응식
[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]=1[N:11]1[CH:15]=[CH:14][CH:13]=[CH:12]1>C(Cl)Cl.[Pd]>[F:1][C:2]1[CH:7]=[C:6]([CH:5]=[CH:4][C:3]=1[N:11]1[CH:15]=[CH:14][CH:13]=[CH:12]1)[NH2:8]참가 물질
4
실험 절차
To a solution of 1-(2-fluoro-4-nitrophenyl)-1H-pyrrole (2.00 g, 9.70 mmol) in CH2Cl2 (35 mL) was added catalyst Pd/C (0.20 g). The reaction mixture was stirred at rt under H2 for 5 h, and filtered. The filtrate was concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/CH2Cl2 (V/V)=3:1) to give the title compound as a white solid (1.30 g, 76%).
후처리
- filtrationfiltered
- concentrationThe filtrate was concentrated in vacuo
- customThe residue was purified by a silica gel column chromatography (PE/CH2Cl2 (V/V)=3:1)
출처 및 근거
- ORD 기록
- ord-117a434a35fe4e83bd2b29ffc765144c
- 출처 데이터셋
- uspto-grants-2016_09
- 특허 번호
- US09434695B2
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