Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 4'-[(4-Methylcyclohexylamino)methyl]biphenyl-3-carboxylic acid amide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | 4-Methylcyclohexylamine | HCID 80604 | — |
| 반응물 | Sodium borohydride | HCID 4311764 | — |
| 반응물 | 4'-Formyl-3-biphenylcarboxamide | HCID 59316529 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 4'-[(4-Methylcyclohexylamino)methyl]biphenyl-3-carboxylic acid amide | HCID 25212824 | — |
반응 단계
To a solution of 4′-formylbiphenyl-3-carboxylic acid amide (700 mg, 3.1 mmol) in methanol (15 mL) was added 4 Å molecular sieves (700 mg) and 4-methylcyclohexylamine (421 mg, 3.7 mmol). The mixture was stirred for 16 h before adding sodium borohydride (588 mg, 15.5 mmol). After 1 h water (10 mL) was added, the mixture was filtered through celite and the solvent removed in vacuo. Purification of the residue by column chromatography (0.5% NH3: 6% MeOH: DCM) gave the title compound: RT=2.53 min; m/z (ES+)=323.0 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08063247B2 |
| 출처 데이터셋 | uspto-grants-2011_11 |
| ORD ID | ord-fdfd0688c00c4d4cbba2615508c03b73 |
| 출처 메모 | uspto-grants-2011_11 |