참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Diisobutylamine | HCID 8085 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1,2-Difluoro-4-nitrobenzene | HCID 123053 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2-fluoro-N,N-diisobutyl-4-nitroaniline | HCID 90023102 | 30% |
반응 단계
To a solution of 3,4-difluoronitrobenzene (1.59 g, 10 mmol) in DMSO (15 mL) were added K2CO3 (3.04 g, 22 mmol) and diisobutylamine (1.42 g, 11 mmol). The mixture was heated at 90° C. overnight, then cooled to rt, diluted with water (50 mL) and extracted with CH2Cl2 (50 mL×3). The combined organic phases were dried over anhydrous Na2SO4 and concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=10:1) to give the title compound as pale yellow oil (0.80 g, 30%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09434695B2 |
|---|
| 출처 데이터셋 | uspto-grants-2016_09 |
|---|
| ORD ID | ord-e8c979772a984cd58c8253213d427499 |
|---|
| 출처 메모 | uspto-grants-2016_09 |
|---|
