Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Chloro-alpha-cyclopropyl-alpha-methylbenzenemethanol → Benzenemethanol, alpha-cyclopropyl-alpha-methyl-4-(trifluoromethyl)-
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Chloro-alpha-cyclopropyl-alpha-methylbenzenemethanol | HCID 23463 | — |
| 반응물 | 1-(4-(Trifluoromethyl)phenyl)ethan-1-one | HCID 69731 | — |
| 반응물 | HCID 178418630 | HCID 178418630 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | Benzenemethanol, alpha-cyclopropyl-alpha-methyl-4-(trifluoromethyl)- | HCID 23255822 | — |
반응 단계
The title compound was prepared starting from 1.50 g (7.97 mmol) of 4′-(trifluoromethyl)acetophenone and 31.9 ml (15.95 mmol) of a 0.5N solution of cyclopropylmagnesium bromide in tetrahydrofuran in analogy to the synthesis of the compound from Example 138A. 1.27 g (69% of theory) of the title compound were obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08063234B2 |
| 출처 데이터셋 | uspto-grants-2011_11 |
| ORD ID | ord-66427df2611d405f8128625bf62943a8 |
| 출처 메모 | uspto-grants-2011_11 |