Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Chloro-alpha-cyclopropyl-alpha-methylbenzenemethanol → alpha-Cyclopropyl-2,3-dihydro-alpha-methyl-1,4-benZodioxin-6-methanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Chloro-alpha-cyclopropyl-alpha-methylbenzenemethanol | HCID 23463 | — |
| 반응물 | 1,4-Benzodioxan-6-yl methyl ketone | HCID 76143 | — |
| 반응물 | HCID 178418630 | HCID 178418630 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | alpha-Cyclopropyl-2,3-dihydro-alpha-methyl-1,4-benZodioxin-6-methanol | HCID 58392439 | — |
반응 단계
The title compound was prepared starting from 1.50 g (8.42 mmol) of 1,4-benzodioxan-6-yl methyl ketone and 33.7 ml (16.84 mmol) of a 0.5N solution of cyclopropylmagnesium bromide in tetrahydrofuran in analogy to the synthesis of the compound from Example 138A. 1.12 g (59% of theory) of the title compound were obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08063234B2 |
| 출처 데이터셋 | uspto-grants-2011_11 |
| ORD ID | ord-1cc945a37750462c96a318d87a9744c5 |
| 출처 메모 | uspto-grants-2011_11 |