Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Chloro-alpha-cyclopropyl-alpha-methylbenzenemethanol → 1-(Benzo[d][1,3]dioxol-5-yl)-1-cyclopropylethanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Chloro-alpha-cyclopropyl-alpha-methylbenzenemethanol | HCID 23463 | — |
| 반응물 | Acetopiperone | HCID 76622 | — |
| 반응물 | HCID 178418630 | HCID 178418630 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 1-(Benzo[d][1,3]dioxol-5-yl)-1-cyclopropylethanol | HCID 58392261 | — |
반응 단계
The title compound was prepared starting from 1.50 g (9.14 mmol) of 3,4-(methylenedioxy)acetophenone and 36.5 ml (18.28 mmol) of a 0.5N solution of cyclopropylmagnesium bromide in tetrahydrofuran in analogy to the synthesis of the compound from Example 138A. 1.32 g (70% of theory) of the title compound were obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08063234B2 |
| 출처 데이터셋 | uspto-grants-2011_11 |
| ORD ID | ord-83377f42d1354a9da6ac332978b01b77 |
| 출처 메모 | uspto-grants-2011_11 |