Ethyl 3-(4-chlorophenyl)-2-methyl-3-{7-[(methylsulfanyl)methyl]-1H-indol-3-yl}propanoate → 3-(4-Chlorophenyl)-2-methyl-3-{7-[(methylsulfanyl)methyl]-1H-indol-3-yl}propan-1-ol

HRID 561532노트

반응식

HRID 561532 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:16]2[C:24]3[C:19](=[C:20]([CH2:25][S:26][CH3:27])[CH:21]=[CH:22][CH:23]=3)[NH:18][CH:17]=2)[CH:9]([CH3:15])[C:10](OCC)=[O:11])=[CH:4][CH:3]=1.BrC1SC(C(C2C3C(=C(CSC)C=CC=3)NC=2)CCO)=CN=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([C:16]2[C:24]3[C:19](=[C:20]([CH2:25][S:26][CH3:27])[CH:21]=[CH:22][CH:23]=3)[NH:18][CH:17]=2)[CH:9]([CH3:15])[CH2:10][OH:11])=[CH:6][CH:7]=1

참가 물질

3

반응물 2

HCID 58392240Ethyl 3-(4-chlorophenyl)-2-methyl-3-{7-[(methylsulfanyl)methyl]-1H-indol-3-yl}propanoateHCID 583924633-(2-Bromo-1,3-thiazol-5-yl)-3-{7-[(methylsulfanyl)methyl]-1H-indol-3-yl}propan-1-ol

생성물 1

HCID 583921743-(4-Chlorophenyl)-2-methyl-3-{7-[(methylsulfanyl)methyl]-1H-indol-3-yl}propan-1-ol

실험 절차

The title compound was prepared starting from 395 mg (0.98 mmol) of the compound from Example 32A in analogy to the synthesis of the compound from Example 19. 222 mg (63% of theory) of the title compound were obtained as mixture of diastereomers.

후처리

  1. customThe title compound was prepared

출처 및 근거

ORD 기록
ord-aa5b0d3e126244ab96a4172da7c67bbd
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08063234B2

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