Triethylamine → HCID 28972568, 화합물

HRID 56157노트

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HRID 56157 반응식
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][NH2:9])[CH2:3][CH2:2]1.F[C:11]1[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][C:12]=1[F:20].CCN(CC)CC>CCOC(C)=O>[F:20][C:12]1[CH:13]=[C:14]([N+:17]([O-:19])=[O:18])[CH:15]=[CH:16][C:11]=1[NH:9][CH2:8][CH2:7][N:4]1[CH2:5][CH2:6][O:1][CH2:2][CH2:3]1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 1230531,2-Difluoro-4-nitrobenzeneHCID 4082852-Morpholinoethylamine

생성물 1

HCID 28972568HCID 28972568, 화합물수율 84.4%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

A solution of 2-morpholinoethanamine (0.90 g, 6.91 mmol), 1,2-difluoro-4-nitrobenzene (1.10 g, 6.91 mmol) and Et3N (1.40 g, 13.82 mmol) in EtOAc (10 mL) was refluxed under N2 for 24 h, then cooled to rt and concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=4:1) to give the title compound as yellow oil (1.57 g, 84%).

후처리

  1. concentrationconcentrated in vacuo
  2. customThe residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=4:1)

출처 및 근거

ORD 기록
ord-8bc05db339de4f0585cf5d122c8a5d69
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434695B2

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