HCID 28972568, 화합물 → 2-fluoro-N1-(2-morpholinoethyl)benzene-1,4-diamine

HRID 56158노트

반응식

HRID 56158 반응식
[F:1][C:2]1[CH:16]=[C:15]([N+:17]([O-])=O)[CH:14]=[CH:13][C:3]=1[NH:4][CH2:5][CH2:6][N:7]1[CH2:12][CH2:11][O:10][CH2:9][CH2:8]1>C1COCC1.[Pd]>[F:1][C:2]1[CH:16]=[C:15]([NH2:17])[CH:14]=[CH:13][C:3]=1[NH:4][CH2:5][CH2:6][N:7]1[CH2:12][CH2:11][O:10][CH2:9][CH2:8]1

참가 물질

4

반응물 1

HCID 28972568HCID 28972568, 화합물

생성물 1

HCID 176096902-fluoro-N1-(2-morpholinoethyl)benzene-1,4-diamine수율 94%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 2-fluoro-N-(2-morpholinoethyl)-4-nitroaniline (0.60 g, 2.23 mmol) in THF (8.0 mL) was added catalyst Pd/C (0.03 g). The reaction mixture was stirred at rt under H2 overnight, then filtered. The filtrate was concentrated in vacuo to give the title compound as yellow oil (0.50 g, 94%).

후처리

  1. filtrationfiltered
  2. concentrationThe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-ceb74fd6c07a4d9aa90d96551da23d0d
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434695B2

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