3-[(4-Fluoro-2-methylphenyl)(4-fluorophenyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indole → 3-[(4-Chloro-2-methylphenyl)(4-fluorophenyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indole

HRID 561585노트

반응식

HRID 561585 반응식
ClC1C=C(Cl)C=CC=1C([C:13]1[C:21]2[C:16](=[C:17]([CH2:23][S:24][CH3:25])[CH:18]=[C:19](F)[CH:20]=2)[NH:15][CH:14]=1)CCO.[Cl:26][C:27]1[CH:32]=[CH:31][C:30]([CH:33]([C:35]2[CH:40]=[CH:39][C:38]([F:41])=[CH:37][CH:36]=2)O)=[C:29]([CH3:42])[CH:28]=1.FC1C=CC(C(C2C=CC(F)=CC=2)C2C3C(=C(CSC)C=CC=3)NC=2)=C(C)C=1>>[Cl:26][C:27]1[CH:32]=[CH:31][C:30]([CH:33]([C:35]2[CH:40]=[CH:39][C:38]([F:41])=[CH:37][CH:36]=2)[C:13]2[C:21]3[C:16](=[C:17]([CH2:23][S:24][CH3:25])[CH:18]=[CH:19][CH:20]=3)[NH:15][CH:14]=2)=[C:29]([CH3:42])[CH:28]=1

참가 물질

4

반응물 3

HCID 445952363-[(4-Fluoro-2-methylphenyl)(4-fluorophenyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indoleHCID 58392095(4-Chloro-2-methylphenyl)(4-fluorophenyl)methanolHCID 583923053-(2,4-Dichlorophenyl)-3-{5-fluoro-7-[(methylsulfanyl)methyl]-1H-indol-3-yl}propan-1-ol

생성물 1

HCID 583922933-[(4-Chloro-2-methylphenyl)(4-fluorophenyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indole

실험 절차

The title compound was prepared starting from 380 mg (2.14 mmol) of the compound from Example 8 and 591 mg (2.36 mmol) of the compound from Example 83A in analogy to the synthesis of the compound from Example 101. 307 mg (35% of theory) of the target compound were obtained.

후처리

  1. custom307 mg (35% of theory) of the target compound were obtained

출처 및 근거

ORD 기록
ord-b92aa700f6da47d08551886697dde726
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08063234B2

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