[O:1]1[C:6]2[CH:7]=[CH:8][C:9]([C:11]([C:19]3[C:27]4[C:22](=[C:23]([CH2:28][S:29][CH3:30])[CH:24]=[CH:25][CH:26]=4)[NH:21][CH:20]=3)([CH3:18])[CH2:12][C:13](OCC)=[O:14])=[CH:10][C:5]=2[O:4][CH2:3][CH2:2]1.[H-].[Al+3].[Li+].[H-].[H-].[H-].O.C(#N)C>O1CCCC1>[O:1]1[C:6]2[CH:7]=[CH:8][C:9]([C:11]([C:19]3[C:27]4[C:22](=[C:23]([CH2:28][S:29][CH3:30])[CH:24]=[CH:25][CH:26]=4)[NH:21][CH:20]=3)([CH3:18])[CH2:12][CH2:13][OH:14])=[CH:10][C:5]=2[O:4][CH2:3][CH2:2]1A solution of 625 mg (1.47 mmol) of the compound from Example 106A in 3 ml of tetrahydrofuran was added dropwise to 5.14 ml (5.14 mmol) of a 1N solution of lithium aluminum hydride in tetrahydrofuran in 6 ml of tetrahydrofuran at RT under argon. The mixture was stirred at 60° C. for 1 h and then mixed with water and acetonitrile, and the suspension was filtered through kieselguhr. The solvents were removed in a rotary evaporator, and the residue was purified by preparative HPLC (mobile phase: acetonitrile/water gradient). 491 mg (87% of theory) of the title compound were obtained.
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