7-[(Methylsulfanyl)methyl]-1H-indole → 3-[1-(4-Chlorophenyl)-1-cyclopropylpropyl]-7-[(methylsulfanyl)methyl]-1H-indole

HRID 561641노트

반응식

HRID 561641 반응식
[CH3:1][S:2][CH2:3][C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:12]=1[NH:11][CH:10]=[CH:9]2.[CH:13]1([C:16]([C:20]2[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][CH:21]=2)(O)[CH2:17][CH3:18])[CH2:15][CH2:14]1.C1(C(C2C3C(=C(CSC)C=CC=3)NC=2)(C2C=CC(OC)=C(F)C=2)C)CC1>>[Cl:26][C:23]1[CH:24]=[CH:25][C:20]([C:16]([C:9]2[C:8]3[C:12](=[C:4]([CH2:3][S:2][CH3:1])[CH:5]=[CH:6][CH:7]=3)[NH:11][CH:10]=2)([CH:13]2[CH2:15][CH2:14]2)[CH2:17][CH3:18])=[CH:21][CH:22]=1

참가 물질

4

반응물 3

HCID 583921877-[(Methylsulfanyl)methyl]-1H-indoleHCID 583923303-[1-Cyclopropyl-1-(3-fluoro-4-methoxyphenyl)ethyl]-7-[(methylsulfanyl)methyl]-1H-indoleHCID 583925071-Cyclopropyl-1-(4-chlorophenyl)propanol

생성물 1

HCID 583921183-[1-(4-Chlorophenyl)-1-cyclopropylpropyl]-7-[(methylsulfanyl)methyl]-1H-indole

실험 절차

The title compound was prepared starting from 84 mg (0.48 mmol) of the compound from Example 8A and 100 mg (0.48 mmol) of the compound from Example 145A in analogy to the synthesis of the compound from Example 186. 38 mg (21% of theory) of the target compound were obtained.

후처리

  1. custom38 mg (21% of theory) of the target compound were obtained

출처 및 근거

ORD 기록
ord-6b98884d3c924f6f9e7ed9854d2eac07
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08063234B2

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