3-(5,7-Difluoro-4-methyl-3,4-dihydro-2H-chromen-4-yl)-7-[(methylsulfanyl)methyl]-1H-indole → 3-(4-Cyclopropyl-5,7-difluoro-3,4-dihydro-2H-chromen-4-yl)-7-[(methylsulfanyl)methyl]-1H-indole

HRID 561644노트

반응식

HRID 561644 반응식
[CH3:1][S:2][CH2:3][C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:12]=1[NH:11][CH:10]=[CH:9]2.[CH:13]1([C:16]2(O)[C:25]3[C:20](=[CH:21][C:22]([F:27])=[CH:23][C:24]=3[F:26])[O:19][CH2:18][CH2:17]2)[CH2:15][CH2:14]1.FC1C=C(F)C=C2C=1C(C1C3C(=C(CSC)C=CC=3)NC=1)(C)CCO2>>[CH:13]1([C:16]2([C:9]3[C:8]4[C:12](=[C:4]([CH2:3][S:2][CH3:1])[CH:5]=[CH:6][CH:7]=4)[NH:11][CH:10]=3)[C:25]3[C:20](=[CH:21][C:22]([F:27])=[CH:23][C:24]=3[F:26])[O:19][CH2:18][CH2:17]2)[CH2:14][CH2:15]1

참가 물질

4

반응물 3

HCID 583920983-(5,7-Difluoro-4-methyl-3,4-dihydro-2H-chromen-4-yl)-7-[(methylsulfanyl)methyl]-1H-indoleHCID 583921877-[(Methylsulfanyl)methyl]-1H-indoleHCID 583922924-Cyclopropyl-5,7-difluoro-3,4-dihydro-2H-chromen-4-ol

생성물 1

HCID 583921713-(4-Cyclopropyl-5,7-difluoro-3,4-dihydro-2H-chromen-4-yl)-7-[(methylsulfanyl)methyl]-1H-indole

실험 절차

The title compound was prepared starting from 450 mg (2.54 mmol) of the compound from Example 8A and 574 mg (2.54 mmol) of the compound from Example 172A in analogy to the synthesis of the compound from Example 193. 80 mg (8% of theory) of the target compound were obtained.

후처리

  1. custom80 mg (8% of theory) of the target compound were obtained

출처 및 근거

ORD 기록
ord-5aebe192bdfc467c843180fbde78fde3
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08063234B2

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