3-[1-Cyclopropyl-1-(2,3-dihydro-1,4-benzodioxin-6-yl)ethyl]-7-[(methylsulfanyl)methyl]-1H-indole → 3-[1-Cyclopropyl-1-(2,3-dihydro-1,4-benzodioxin-6-yl)ethyl]-7-[(methylsulfonyl)methyl]-1H-indole

HRID 561649노트

반응식

HRID 561649 반응식
C1(C(C2C3C(=C(CSC)C=CC=3)NC=2)(C2C=C[C:9]3[O:10]CC[O:13][C:8]=3C=2)C)CC1.Cl[C:29]1[CH:34]=[CH:33][C:32]([C:35]([C:40]2[C:48]3[C:43](=[C:44]([CH2:49][S:50]([CH3:53])(=[O:52])=[O:51])[CH:45]=[CH:46][CH:47]=3)[NH:42][CH:41]=2)([CH:37]2[CH2:39][CH2:38]2)[CH3:36])=[CH:31][CH:30]=1>>[CH:37]1([C:35]([C:40]2[C:48]3[C:43](=[C:44]([CH2:49][S:50]([CH3:53])(=[O:52])=[O:51])[CH:45]=[CH:46][CH:47]=3)[NH:42][CH:41]=2)([C:32]2[CH:33]=[CH:34][C:29]3[O:10][CH2:9][CH2:8][O:13][C:30]=3[CH:31]=2)[CH3:36])[CH2:39][CH2:38]1

참가 물질

3

반응물 2

HCID 445953853-[1-Cyclopropyl-1-(2,3-dihydro-1,4-benzodioxin-6-yl)ethyl]-7-[(methylsulfanyl)methyl]-1H-indoleHCID 583923883-[1-(4-Chlorophenyl)-1-cyclopropylethyl]-7-[(methylsulfonyl)methyl]-1H-indole

생성물 1

HCID 583923733-[1-Cyclopropyl-1-(2,3-dihydro-1,4-benzodioxin-6-yl)ethyl]-7-[(methylsulfonyl)methyl]-1H-indole

실험 절차

The title compound was prepared starting from 94 mg (0.25 mmol) of the compound from Example 188 in analogy to the synthesis of the compound from Example 209. 56 mg (55% of theory) of the target compound were obtained.

후처리

  1. custom56 mg (55% of theory) of the target compound were obtained

출처 및 근거

ORD 기록
ord-15ff84dfa1be4cf88d07f4f83287b4f4
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08063234B2

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