Ethyl Acetate → 2-fluoro-N1-(3-morpholinopropyl)benzene-1,4-diamine

HRID 56165노트

반응식

HRID 56165 반응식
[F:1][C:2]1[CH:17]=[C:16]([N+:18]([O-])=O)[CH:15]=[CH:14][C:3]=1[NH:4][CH2:5][CH2:6][CH2:7][N:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1.CCOC(C)=O>[Pd].CO>[F:1][C:2]1[CH:17]=[C:16]([NH2:18])[CH:15]=[CH:14][C:3]=1[NH:4][CH2:5][CH2:6][CH2:7][N:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1

참가 물질

5

반응물 2

HCID 8857Ethyl AcetateHCID 29277432-fluoro-N-(3-morpholinopropyl)-4-nitroaniline

생성물 1

HCID 431684652-fluoro-N1-(3-morpholinopropyl)benzene-1,4-diamine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a solution of 2-fluoro-N-(3-morpholinopropyl)-4-nitroaniline (1.78 g, 6.28 mmol) in mixed solvents of EtOAc (15 mL) and MeOH (15 mL) was added catalyst Pd/C (0.30 g). The reaction was stirred at rt under H2 for 2 h, then filtered. The filtrate was concentrated in vacuo to give the crude product for the next step without further purification.

후처리

  1. filtrationfiltered
  2. concentrationThe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-60f431a2f98345b1b92c44836d7122b0
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434695B2

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