3-[1-(4-Chlorophenyl)-1-cyclopropylpropyl]-7-[(methylsulfanyl)methyl]-1H-indole → 3-[1-(4-Chlorophenyl)-1-cyclopropylpropyl]-7-[(methylsulfonyl)methyl]-1H-indole

HRID 561652노트

반응식

HRID 561652 반응식
Cl[C:2]1C=CC(C(C2C3C(=C(CSC)C=CC=3)NC=2)(C2CC2)CC)=CC=1.[Cl:26][C:27]1[CH:32]=[CH:31][C:30]([C:33]([C:38]2[C:46]3[C:41](=[C:42]([CH2:47][S:48]([CH3:51])(=[O:50])=[O:49])[CH:43]=[CH:44][CH:45]=3)[NH:40][CH:39]=2)([CH:35]2[CH2:37][CH2:36]2)[CH3:34])=[CH:29][CH:28]=1>>[Cl:26][C:27]1[CH:32]=[CH:31][C:30]([C:33]([C:38]2[C:46]3[C:41](=[C:42]([CH2:47][S:48]([CH3:51])(=[O:50])=[O:49])[CH:43]=[CH:44][CH:45]=3)[NH:40][CH:39]=2)([CH:35]2[CH2:37][CH2:36]2)[CH2:34][CH3:2])=[CH:29][CH:28]=1

참가 물질

3

반응물 2

HCID 583921183-[1-(4-Chlorophenyl)-1-cyclopropylpropyl]-7-[(methylsulfanyl)methyl]-1H-indoleHCID 583923883-[1-(4-Chlorophenyl)-1-cyclopropylethyl]-7-[(methylsulfonyl)methyl]-1H-indole

생성물 1

HCID 583924303-[1-(4-Chlorophenyl)-1-cyclopropylpropyl]-7-[(methylsulfonyl)methyl]-1H-indole

실험 절차

The title compound was prepared starting from 116 mg (0.31 mmol) of the compound from Example 191 in analogy to the synthesis of the compound from Example 209. 98 mg (78% of theory) of the target compound were obtained.

후처리

  1. custom98 mg (78% of theory) of the target compound were obtained

출처 및 근거

ORD 기록
ord-f93de2d4e43d4a72b545865e16e0a72f
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08063234B2

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