3-[(4-Chlorophenyl)(cyclopropyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indole → 3-[(2-Chloro-4-fluorophenyl)(cyclopropyl)methyl]-5-fluoro-7-[(methylsulfanyl) methyl]-1H-indole

HRID 561664노트

반응식

HRID 561664 반응식
[F:1]C1C=C2C(=C(CSC)C=1)NC=C2.[Cl:14][C:15]1[CH:20]=[C:19](F)[C:18](C(C2CC2)O)=[C:17]([F:27])[CH:16]=1.ClC1C=CC([CH:35]([CH:48]2[CH2:50][CH2:49]2)[C:36]2[C:44]3[C:39](=[C:40]([CH2:45][S:46][CH3:47])[CH:41]=[CH:42][CH:43]=3)[NH:38][CH:37]=2)=CC=1>>[Cl:14][C:15]1[CH:16]=[C:17]([F:27])[CH:18]=[CH:19][C:20]=1[CH:35]([CH:48]1[CH2:49][CH2:50]1)[C:36]1[C:44]2[C:39](=[C:40]([CH2:45][S:46][CH3:47])[CH:41]=[C:42]([F:1])[CH:43]=2)[NH:38][CH:37]=1

참가 물질

4

반응물 3

HCID 583921383-[(4-Chlorophenyl)(cyclopropyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indoleHCID 583922275-Fluoro-7-[(methylsulfanyl)methyl]-1H-indoleHCID 58392245(4-Chloro-2,6-difluorophenyl)(cyclopropyl)methanol

생성물 1

HCID 583924223-[(2-Chloro-4-fluorophenyl)(cyclopropyl)methyl]-5-fluoro-7-[(methylsulfanyl) methyl]-1H-indole

실험 절차

The title compound was prepared starting from 200 mg (1.02 mmol) of the compound from Example 11A and 206 mg (1.02 mmol) of the compound from Example 156A in analogy to the synthesis of the compound from Example 227. 247 mg (64% of theory) of the target compound were obtained.

후처리

  1. custom247 mg (64% of theory) of the target compound were obtained

출처 및 근거

ORD 기록
ord-75be6ef4c98644fbb6c6807574c0d6b1
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08063234B2

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