4-Chloro-alpha-cyclopropylbenzenemethanol → 3-[(4-Chlorophenyl)(cyclopropyl)methyl]-6-fluoro-7-[(methylsulfanyl)methyl]-1H-indole

HRID 561666노트

반응식

HRID 561666 반응식
[F:1][C:2]1[C:10]([CH2:11][S:12][CH3:13])=[C:9]2[C:5]([CH:6]=[CH:7][NH:8]2)=[CH:4][CH:3]=1.[CH:14]1([CH:17]([C:19]2[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=2)O)[CH2:16][CH2:15]1.ClC1C=C(F)C=CC=1C(C1CC1)C1C2C(=C(CSC)C(F)=CC=2)NC=1>>[Cl:25][C:22]1[CH:23]=[CH:24][C:19]([CH:17]([CH:14]2[CH2:15][CH2:16]2)[C:6]2[C:5]3[C:9](=[C:10]([CH2:11][S:12][CH3:13])[C:2]([F:1])=[CH:3][CH:4]=3)[NH:8][CH:7]=2)=[CH:20][CH:21]=1

참가 물질

4

반응물 3

HCID 866794-Chloro-alpha-cyclopropylbenzenemethanolHCID 583922596-Fluoro-7-[(methylsulfanyl)methyl]-1H-indoleHCID 583924123-[(2-Chloro-4-fluorophenyl)(cyclopropyl)methyl]-6-fluoro-7-[(methylsulfanyl)methyl]-1H-indole

생성물 1

HCID 583923763-[(4-Chlorophenyl)(cyclopropyl)methyl]-6-fluoro-7-[(methylsulfanyl)methyl]-1H-indole

실험 절차

The title compound was prepared starting from 500 mg (2.56 mmol) of the compound from Example 9A and 468 mg (2.56 mmol) of the compound from Example 153A in analogy to the synthesis of the compound from Example 233. 411 mg (44% of theory) of the target compound were obtained.

후처리

  1. custom411 mg (44% of theory) of the target compound were obtained

출처 및 근거

ORD 기록
ord-2239be35a4a0473888e3f35ed2732490
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08063234B2

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