3-[(4-Chlorophenyl)(cyclopropyl)methyl]-7-[(methylsulfonyl)methyl]-1H-indole → 3-[Cyclopropyl(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]-7-[(methylsulfonyl)methyl]-1H-indole

HRID 561674노트

반응식

HRID 561674 반응식
C1(C(C2C=CC3[O:21][C:22]([F:25])([F:24])[O:23]C=3C=2)C2C3C(=C(CSC)C=CC=3)NC=2)CC1.Cl[C:29]1[CH:34]=[CH:33][C:32]([CH:35]([CH:50]2[CH2:52][CH2:51]2)[C:36]2[C:44]3[C:39](=[C:40]([CH2:45][S:46]([CH3:49])(=[O:48])=[O:47])[CH:41]=[CH:42][CH:43]=3)[NH:38][CH:37]=2)=[CH:31][CH:30]=1>>[CH:50]1([CH:35]([C:32]2[CH:33]=[CH:34][C:29]3[O:21][C:22]([F:25])([F:24])[O:23][C:30]=3[CH:31]=2)[C:36]2[C:44]3[C:39](=[C:40]([CH2:45][S:46]([CH3:49])(=[O:48])=[O:47])[CH:41]=[CH:42][CH:43]=3)[NH:38][CH:37]=2)[CH2:52][CH2:51]1

참가 물질

3

반응물 2

HCID 583920863-[(4-Chlorophenyl)(cyclopropyl)methyl]-7-[(methylsulfonyl)methyl]-1H-indoleHCID 583923293-[Cyclopropyl(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]-7-[(methylsulfanyl)methyl]-1H-indole

생성물 1

HCID 583921423-[Cyclopropyl(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]-7-[(methylsulfonyl)methyl]-1H-indole

실험 절차

The title compound was prepared starting from 500 mg (1.29 mmol) of the compound from Example 231 in analogy to the synthesis of the compound from Example 249. A difference was that the reaction solution was washed with saturated aqueous sodium bicarbonate solution before purification. 311 mg (57% of theory) of the target compound were obtained.

후처리

  1. washwas washed with saturated aqueous sodium bicarbonate solution before purification
  2. custom311 mg (57% of theory) of the target compound were obtained

출처 및 근거

ORD 기록
ord-0634e8819da34e8e9df21eeb8469b84c
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08063234B2

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