3-[(4-Chlorophenyl)(cyclopropyl)methyl]-6-fluoro-7-[(methylsulfanyl)methyl]-1H-indole → 3-[(4-Chlorophenyl)(cyclopropyl)methyl]-6-fluoro-7-[(methylsulfonyl)methyl]-1H-indole

HRID 561678노트

반응식

HRID 561678 반응식
ClC1C=CC(C(C2CC2)C2C3C(=C(CSC)C([F:18])=CC=3)NC=2)=CC=1.[Cl:25][C:26]1[CH:31]=[CH:30][C:29]([C:32]([C:37]2[C:45]3[C:40](=[C:41]([CH2:46][S:47]([CH3:50])(=[O:49])=[O:48])[CH:42]=[CH:43][CH:44]=3)[NH:39][CH:38]=2)([CH:34]2[CH2:36][CH2:35]2)C)=[CH:28][CH:27]=1>>[Cl:25][C:26]1[CH:31]=[CH:30][C:29]([CH:32]([CH:34]2[CH2:36][CH2:35]2)[C:37]2[C:45]3[C:40](=[C:41]([CH2:46][S:47]([CH3:50])(=[O:49])=[O:48])[C:42]([F:18])=[CH:43][CH:44]=3)[NH:39][CH:38]=2)=[CH:28][CH:27]=1

참가 물질

3

반응물 2

HCID 583923763-[(4-Chlorophenyl)(cyclopropyl)methyl]-6-fluoro-7-[(methylsulfanyl)methyl]-1H-indoleHCID 583923883-[1-(4-Chlorophenyl)-1-cyclopropylethyl]-7-[(methylsulfonyl)methyl]-1H-indole

생성물 1

HCID 592939413-[(4-Chlorophenyl)(cyclopropyl)methyl]-6-fluoro-7-[(methylsulfonyl)methyl]-1H-indole

실험 절차

The title compound was prepared starting from 238 mg (0.66 mmol) of the compound from Example 234 in analogy to the synthesis of the compound from Example 209. 144 mg (55% of theory) of the target compound were obtained.

후처리

  1. custom144 mg (55% of theory) of the target compound were obtained

출처 및 근거

ORD 기록
ord-709d663b02ad427e9810a59d429620d6
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08063234B2

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