4-Morpholinebutanenitrile → 4-(Morpholin-4-yl)butan-1-amine

HRID 56168

반응식

HRID 56168 반응식
[H-].[H-].[H-].[H-].[Li+].[Al+3].[O:7]1[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][CH2:15][C:16]#[N:17])[CH2:9][CH2:8]1>C1COCC1.O>[O:7]1[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][CH2:15][CH2:16][NH2:17])[CH2:9][CH2:8]1

참가 물질

5

반응물 2

HCID 2945744-MorpholinebutanenitrileHCID 21226445Aluminium lithium hydride

생성물 1

HCID 2336114-(Morpholin-4-yl)butan-1-amine

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매2회

반응 조건

온도
0 °C

실험 절차

To anhydrous THF (70 mL) was added LiAlH4 (5.37 g, 142 mmol) in one portion. The mixture was stirred at 0° C. for 20 min, and a solution of 4-morpholinobutanenitrile (7.26 g, 47 mmol) in anhydrous THF (40 mL) was added dropwise. Upon the end of addition the mixture was refluxed for 4 h, then cooled to 0° C., diluted with water (20 mL) and filtered. The filtrate was concentrated in vacuo to give the crude product for the next step without further purification.

후처리

  1. additionUpon the end of addition the mixture
  2. temperaturewas refluxed for 4 h
  3. temperaturecooled to 0° C.
  4. filtrationfiltered
  5. concentrationThe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-2c9a79470dd24e1c8cfc412f9d1e7bf0
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434695B2

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