Potassium Carbonate → 2-fluoro-N-(4-morpholinobutyl)-4-nitroaniline

HRID 56169

반응식

HRID 56169 반응식
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][CH2:9][CH2:10][NH2:11])[CH2:3][CH2:2]1.F[C:13]1[CH:18]=[CH:17][C:16]([N+:19]([O-:21])=[O:20])=[CH:15][C:14]=1[F:22].C([O-])([O-])=O.[K+].[K+]>C(#N)C>[F:22][C:14]1[CH:15]=[C:16]([N+:19]([O-:21])=[O:20])[CH:17]=[CH:18][C:13]=1[NH:11][CH2:10][CH2:9][CH2:8][CH2:7][N:4]1[CH2:5][CH2:6][O:1][CH2:2][CH2:3]1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 1230531,2-Difluoro-4-nitrobenzeneHCID 2336114-(Morpholin-4-yl)butan-1-amine

생성물 1

HCID 1179660642-fluoro-N-(4-morpholinobutyl)-4-nitroaniline

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A suspension of 4-morpholinobutan-1-amine (0.63 g, 4.00 mmol), 1,2-difluoro-4-nitrobenzene (0.64 g, 4.00 mmol) and K2CO3 (1.10 g, 8.00 mmol) in acetonitrile (20 mL) was stirred at rt for 19 h under N2, then filtered. The filtrate was concentrated in vacuo to give the crude product for the next step without further purification.

후처리

  1. filtrationfiltered
  2. concentrationThe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-3a675810b1134632b765617e574da304
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434695B2

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