3-[Bis(4-chlorophenyl)methyl]-7-[(methylsulfinyl)methyl]-1H-indole → 3-[(4-Chlorophenyl)(4-fluorophenyl)methyl]-5-fluoro-7-[(methylsulfinyl)methyl]-1H-indole
반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:22]2[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=2)[C:9]2[C:17]3[C:12](=[C:13]([CH2:19][S:20][CH3:21])[CH:14]=[C:15]([F:18])[CH:16]=3)[NH:11][CH:10]=2)=[CH:4][CH:3]=1.ClC1C=CC(C(C2C=CC(Cl)=CC=2)C2C3C(=C(CS(C)=[O:48])C=CC=3)NC=2)=CC=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:22]2[CH:23]=[CH:24][C:25]([F:28])=[CH:26][CH:27]=2)[C:9]2[C:17]3[C:12](=[C:13]([CH2:19][S:20]([CH3:21])=[O:48])[CH:14]=[C:15]([F:18])[CH:16]=3)[NH:11][CH:10]=2)=[CH:4][CH:3]=1참가 물질
3
실험 절차
The title compound was prepared starting from 100 mg (0.24 mmol) of the compound from Example 291 in analogy to the synthesis of the compound from Example 296. 102 mg (98% of theory) of the target compound were obtained as mixture of diastereomers.
후처리
- custom102 mg (98% of theory) of the target compound were obtained as mixture of diastereomers