3-[Bis(4-chlorophenyl)methyl]-7-[(methylsulfonyl)methyl]-1H-indole → 3-[(4-Chlorophenyl)(4-methoxyphenyl)methyl]-7-[(methylsulfonyl)methyl]-1H-indole

HRID 561722노트

반응식

HRID 561722 반응식
ClC1C=CC(C(C2C=C[C:24]([O:27]C)=CC=2)C2C3C(=C(CSC)C=CC=3)NC=2)=CC=1.[Cl:29][C:30]1[CH:35]=[CH:34][C:33]([CH:36]([C:51]2[CH:56]=[CH:55][C:54](Cl)=[CH:53][CH:52]=2)[C:37]2[C:45]3[C:40](=[C:41]([CH2:46][S:47]([CH3:50])(=[O:49])=[O:48])[CH:42]=[CH:43][CH:44]=3)[NH:39][CH:38]=2)=[CH:32][CH:31]=1>>[Cl:29][C:30]1[CH:35]=[CH:34][C:33]([CH:36]([C:51]2[CH:56]=[CH:55][C:54]([O:27][CH3:24])=[CH:53][CH:52]=2)[C:37]2[C:45]3[C:40](=[C:41]([CH2:46][S:47]([CH3:50])(=[O:49])=[O:48])[CH:42]=[CH:43][CH:44]=3)[NH:39][CH:38]=2)=[CH:32][CH:31]=1

참가 물질

3

반응물 2

HCID 583923823-[Bis(4-chlorophenyl)methyl]-7-[(methylsulfonyl)methyl]-1H-indoleHCID 583924453-[(4-Chlorophenyl)(4-methoxyphenyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indole

생성물 1

HCID 583924833-[(4-Chlorophenyl)(4-methoxyphenyl)methyl]-7-[(methylsulfonyl)methyl]-1H-indole

실험 절차

The title compound was prepared starting from 150 mg (0.37 mmol) of the compound from Example 282 in analogy to the synthesis of the compound from Example 312. 130 mg (80% of theory) of the target compound were obtained.

후처리

  1. custom130 mg (80% of theory) of the target compound were obtained

출처 및 근거

ORD 기록
ord-4d3bad5181b441509b5a26efbe1198ee
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08063234B2

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